Research Assistant

Job Description

Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder. 

Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:

1) Validation of prioritized oncogenic RE-derived chimeric transcripts 

2) Immunopeptidome validation of high-affinity scoring RE peptides



Qualifications

BSc
MSc



Skills

Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder. 

Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:

1) Validation of prioritized oncogenic RE-derived chimeric transcripts 

2) Immunopeptidome validation of high-affinity scoring RE peptides

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Post doc to carry out work on cell models of Tau-related dementias



Qualifications

PhD



Skills

Super resolution imaging, cell culture, BQ-BSA assays, high content imaging, western blotting

The successful candidate will review a set of lecture notes and slides designed for an undergraduate mathematics course. The course covers fundamental topics such as basic mathematical functions, trigonometry, differentiation, integration, and introductory probability theory and inference.

The candidate?s primary responsibility will be to help to bridge the gap between mathematics and the natural sciences by relating the mathematical content to examples from the sciences and by linking the mathematical formalism to conventions (mathematical notation  etc.) more commonly used in scientific disciplines. There will also be the opportunity to work with staff in the maths department on the formatting and presentation of content and on the design of assessments. 



Qualifications

Undergraduate level or higher degree in a mathematical science (Engineering or Physics preferred)



Skills
  • A good understanding of the mathematics required for undergraduate science programmes is essential.
  • Experience of delivering undergraduate level mathematics tuition is desirable.
  • Experience of supporting preparation of teaching materials for undergraduate mathematics teaching is desirable.

The team 

King?s Careers & Employability (KC&E) seeks to enable and empower students, recent alumni, and researchers from all disciplines and walks of life, to gain the knowledge, skills, and experiences they need to effectively navigate their lives and careers after university and achieve lifelong success. 

The Marketing & Communications Assistant sits within the Student Careers Engagement (SCE) team within the department. The SCE team supports students at all levels across the institution, as well as alumni, to access information, advice, events, opportunities, and e-learning, to aid them in their career journeys. As a team, we also work specifically to address the sector-wide and institutional factors and barriers that contribute to differences in progression amongst students from underrepresented backgrounds. 

About the Role  

The Marketing & Communications Assistant will work closely with the Marketing & Communications Officer to plan and execute the communication plan for King?s Careers & Employability.  Key projects will include planning and executing communications for the core events and opportunities we run in the Autumn term, creating and managing a pool of collaborative content, and ensuring we collect engagement-related data to inform our communication activities. The post-holder will also be required to produce engaging design work for print, social media, and other online assets, using our branding guidelines. You will work closely with other colleagues across the department, working on multiple projects simultaneously.  

This role would suit someone who is looking to gain experience in marketing and communications, as well as working in a Higher Education context. 

Key Responsibilities  

  1. Designing a range of engaging content, in line with the department?s branding guidelines.  
  2. Assisting with planning and executing marketing and communications campaigns, promoting our key services and events to students. 
  3. Assisting with creating content to grow and develop our social media platforms.  

 

Applications for this role will close on Sunday 1st September at 11:59pm. Interviews will take place on Thursday 12th September on MS Teams. You must be available on this day for the interview. Applications must be submitted through King?s Talent Bank. Please provide clear examples of how you meet the essential criteria (and desirable if applicable) in your cover letter, along with motivations for applying for the role. You must be available for a start date on Monday 16th September. 



Qualifications

N/A



Skills

Skills, Knowledge and Experience  

Essential:  

  1. Strong written communication skills. 
  2. Attention to detail and ability to multi-task. 
  3. Ability to show initiative and feel confident in pitching new ideas. 
  4. Commitment to equality, diversity, and inclusion, and embedding this into your work. 
  5. Interest in content creation to help promote our services and opportunities. 

 

Desirable  

  1. Familiarity with design and editing platforms such as Canva, Capcut or similar.  
  2. Experience using social media or other content management systems to promote products or services. 
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