Invigilator

Post doc to carry out work on cell models of Tau-related dementias

PhD

Super resolution imaging, cell culture, BQ-BSA assays, high content imaging, western blotting

Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder. 

Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:

1) Validation of prioritized oncogenic RE-derived chimeric transcripts 

2) Immunopeptidome validation of high-affinity scoring RE peptides

BSc
MSc

Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder. 

Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:

1) Validation of prioritized oncogenic RE-derived chimeric transcripts 

2) Immunopeptidome validation of high-affinity scoring RE peptides

The successful candidate will review a set of lecture notes and slides designed for an undergraduate mathematics course. The course covers fundamental topics such as basic mathematical functions, trigonometry, differentiation, integration, and introductory probability theory and inference.

The candidate?s primary responsibility will be to help to bridge the gap between mathematics and the natural sciences by relating the mathematical content to examples from the sciences and by linking the mathematical formalism to conventions (mathematical notation  etc.) more commonly used in scientific disciplines. There will also be the opportunity to work with staff in the maths department on the formatting and presentation of content and on the design of assessments. 

Undergraduate level or higher degree in a mathematical science (Engineering or Physics preferred)

• A good understanding of the mathematics required for undergraduate science programmes is essential.
• Experience of delivering undergraduate level mathematics tuition is desirable.
• Experience of supporting preparation of teaching materials for undergraduate mathematics teaching is desirable.